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Effectiveness Of Intra-Articular Tranexamic Acid Soaking On Blood Loss During Total Knee Arthroplasty
ESSKA Academy. Kim Y. 05/09/18; 212751; P11-1076 Topic: Joint Replacement
Young-Mo Kim
Young-Mo Kim
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Abstract
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Objectives: To evaluate the effectiveness of intra-articular tranexamic acid (TXA) soaking on blood loss during total knee arthroplasty.

Methods: We evaluated 85 patients who underwent primary total knee arthroplasty from January 2015 to March 2016. 100 patients were randomized to TXA group (50 patients) or control group (50 patients). In TXA group, 15ml of TXA in 100mL of normal saline was soaked for 5 minutes after prosthesis implantation but before capsule close. Drain was maintained with neutral pressure and turned on negative pressure three times a day for 30 minutes at a time. Drain was removed at 72 hours postoperatively. Hemoglobin, hematocrit, blood transfusion rate, drainage volume and lower extremity deep vein thrombosis (DVT) rate were evaluated in both groups. All patients underwent ultrasonography of the operative extremity at postoperative 7 days.

Results: Total drainage volume and blood transfusion rate were lower in the TXA group. Drain volume was 309.46 ml in TXA group and 863.47ml in control grope.Transfusion rate were 26.19% in TKa group and 97.3 % in control group.
Postoperative hemoglobin, hematocrit were higher in the TXA group than the control group.
Postoperative hemoglobin, hematocrit were 10.47g/dl, 31.07% in TXA group and 8,41 g/dl, 23.64% in control group.
There was no significant difference in DVT rate and other complications between the two groups.

Conclusions: Intra-articular TXA soaking during total knee arthroplasty is effective method for decreasing blood loss and blood transfusion rate.

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