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Platelet-Rich Plasma Intra-articular Knee Injections Versus Viscosupplementation: Long-term Results of A Randomized Controlled Trial
ESSKA Academy. Filardo G. May 11, 2018; 218120
Giuseppe Filardo
Giuseppe Filardo
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Abstract
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Objectives: To compare the long-term clinical outcome of intra-articular injections of either Platelet Rich Plasma (PRP) or Hyaluronic acid (HA) to treat knee degenerative pathology.

Methods: 167 patients with unilateral symptomatic knee with history of chronic pain or swelling and imaging findings of degenerative changes underwent 3 weekly injections of either PRP or HA and were prospectively evaluated basally and then at 2, 6, 12, 24 and mean 64.3 (+- 7.8) months of follow-up using IKDCsubj, KOOS, EQ-VAS, and Tegner scores.

Results: Both treatments were effective in function and symptoms: IKDCsubj score in PRP rose from 52.4±14.1 to 66.2±16.7 at 12m (p<0.0005), in HA group from 49.6±13.0 to 64.2±18.0 at 12m (p<0.0005). Stable results were documented up to 24 months, a slight not significant decrease was observed in both treatments at the final 64.3 months' evaluation. The comparative analysis showed no significant inter-group difference at any follow-up evaluation in any of the clinical scores, except for the rate of re-intervention at 24m which was significantly higher in HA group (38.2% vs 21.5%, p=0.034).

Conclusions: PRP does not provide a superior clinical improvement with respect to HA, and therefore it should not be preferred to viscosupplementation as a first line injective treatment of patients affected by knee cartilage degeneration and osteoarthritis.

Keywords:
PRP, knee, osteoarthritis, Hyaluronic acid
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